David R. McClay, Ph.D.
Arthur S. Pearse Professor of Biology
Professor of Neurobiology
Professor of Marine Science

Professor McClay’s research asks how early embryonic development proceeds at a molecular level. He studies transcriptional networks and signal transduction mechanisms that program an increasing diversity of cell types in the embryo. The sea urchin embryo and the chick embryos are used as model organisms for study.
link to full bio

Publications:
Peterson, R. E. and D.R. McClay (2005) A Fringe-modified Notch signal affects specification of mesoderm and endoderm in the sea urchin embryo.
Dev. Biol. In press.

Range, R., J. Venuti, and D.R. McClay (2005) LvGroucho and nuclear ß-catenin functionally competefor Tcf binding to influence activation of the endomesoderm gene regulatory network in the sea urchin embryo. Dev Biol, 279:252-267.

Otim O, Amore G, Minokawa T, McClay DR, Davidson EH. (2004) SpHnf6, a transcription factor that executes multiple functions in sea urchin embryogenesis. Dev Biol.273:226- 243.

McClay, D.R., Gross, J., Peterson, R. and C. Bradham. (2004) Mechanism of gastrulation in the Sea urchin. In "Gastrulation" (CD. Stern Ed) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. pp. 123-138.