Environment General Courses (ENVIRON)

graduate level, taught in Durham

298.60 Integrative and Comparative Pathobiology for Toxicologists
This will be a lecture and laboratory (computer-based and using mounted photomicrographs) course emphasizing basic concepts and terminology of cells, tissues and organs. Using the mammalian anatomical plan and its major alterations in acute and chronic toxicity, the course seeks to acquaint the student with the skills necessary to integrate molecular findings/responses to those of cells, tissues, organs and organ systems. Specific topics include: cellular adaptation and cell injury; pathogenesis and morphology of cell injury and death, intra- and extra-cellular accumulations; circulatory disturbances including hemorrhage, thrombosis and edema; biochemical mediators and cells of inflammation; forms of inflammation and repair; host &parasite interactions in disease; alterations in growth; biology of neoplastic and malignant cells; and, mechanisms of carcinogenesis.
Next, the course will cover specific organ systems reviewing dynamic anatomy and emphasizing features of toxicity. The major aim is to integrate form with altered function enabling the student to move from molecular derangement to phenotype. Circulatory, musculoskeletal, digestive, nervous, integumentary, reproductive, respiratory, and urinary systems will be covered.